Gastric and Duodenal ulceration

Causes of ulceration

Gastric, oesophageal and duodenal ulcers can occur as a result of damage to the protective lining of the gastro-intestinal tract. This damage can occur for a number of reasons but normally is due to;


Symptoms of gastric or duodenal ulcers

Symptoms largely depend on the location of the ulcer in the GI tract. If the ulcer is located in the duodenum, pain and discomfort usually presents on an empty stomach or a couple of hours after a meal. If the ulcer is located in the stomach the pain tends to get worse after meals. An ulcer in the oesophagus can cause dysphagia (difficulty swallowing) or lower chest pain.

The following are all symptoms of a peptic ulcer:


When to refer

Patients who present with the following symptoms should be referred urgently to their GP:


Treatment options 

1. Lifestyle intervention

2. Drug treatment


Which NSAIDs are most commonly associated with GI ulceration?